Chlorambucil

Chlorambucil 60 tabs x 20 mg
Substance

Packing:

Each box contains 60 pills

Composition:

A pill contains 20 mg of Cyproterone.

Indications:

Chlorambucil is used to treat several types of cancer, including Hodgkin's disease and certain types of leukemia or lymphoma.

Contra - indications:

Do not use this drug if you are allergic to any ingredient in chlorambucil

  • you have taken chlorambucil before and your cancer did not respond

  • you are in the first trimester of pregnancy

  • you have taken or will be taking palifermin within 24 hours of taking chlorambucil

FDA pregnancy category D. Do not use chlorambucil if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

This medication may affect fertility (your ability to have children) whether you are a man or a woman.

It is not known whether chlorambucil passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Contact your doctor or health care provider right away if any of these apply to you.

Administration:

For initiation of therapy or for short courses of treatment: Usual Dosage: 0.1 to 0.2 mg/kg orally daily for 3 to 6 weeks as required. (This usually amounts to 4 to 10 mg per day for the average patient.) The entire daily dose may be given at one time. The dosage must be carefully adjusted according to the response of the patient and must be reduced as soon as there is an abrupt fall in the white blood cell count. Patients with Hodgkin's disease usually require 0.2 mg/kg daily. Patients with other lymphomas or chronic lymphocytic leukemia usually require only 0.1 mg/kg daily. When lymphocytic infiltration of the bone marrow is present, or when the bone marrow is hypoplastic, the daily dose should not exceed 0.1 mg/kg (about 6 mg for the average patient).



Medical action:

Alkylating agents derived from the nitrogen mustards from which, among other things as war gasses were used. Their activity against cancer cells based on the alkylation of nucleic acids (DNA, RNA), resulting in different modifications: abnormal base pairing, crosslinking of DNA or RNA strands.

Like other alkylating agents, chlorambucil affects not cycle specific but has mainly an effect on cells which are in the G1 - or S-phase of the cell cycle are. The cytocidal effect is so especially during DNAsynthesis, the replication, noticeable.

Precautions:

Some medical conditions may interact with chlorambucil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breastfeeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have had an allergic reaction to any other alkylating agent (eg, cyclophosphamide)

  • if you are able to become pregnant

  • if you have liver problems, bone marrow problems (eg, low white blood cell counts, low blood platelet levels), the blood disease porphyria, an infection, shingles, or chickenpox

  • if you have a history of seizures or head injury

  • if you are receiving or have recently received (within the past 4 weeks) radiation therapy or treatment with other cancer medicines

  • if you take any medicine that may increase the risk of seizures. Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of seizures

Some medicines may interact with chlorambucil. Tell your health care provider if you are taking any other medicines, especially the following:

  • Palifermin because the risk of increased severity and duration of mouth or tongue sores may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if chlorambucil may interact with other medicines that you take. Check with your health care provider before you start, stop or change the dose of any medicine.



Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Diarrhea.

Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); absence of menstrual period; agitation; burning, numbness, or tingling; confusion; dark, tarry, or bloody stools; decreased coordination; fever, chills, or persistent cough or sore throat; hallucinations; limp muscles or inability to move; muscle twitching; nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath or difficulty breathing; sores in the mouth or on the lips; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, stomach pain, yellowing of the skin or eyes); tremors; unusual bruising or bleeding; unusual lumps or growths; unusual tiredness or weakness; vomiting.



Overdosage:

If an overdose situation happens seek emergency help.