Chloropyramine

Chloropyramine 60 tabs x 25 mg
Substance

Packing:

Each box contains 60 pills.

Composition:

A pill contains 25 mg of Chloropyramine.

Indications:

In the form of solution for injection, it is used in acute allergic reactions related to urticaria treatment (due to foods, medicines, helminths, etc.) and insect bite; in allergic reactions of general type (anaphylactic shock, serum disease, Quincke’s edema), when the product is used as a part of the complex therapy. In the form of tablets: for the treatment of allergic rhinitis, conjunctivitis, hay fever, drug and food allergy, allergic reactions after the insect bite. In the form of ointment or cream, it is used for the treatment of allergic skin reactions.

Contra - indications:

The solution for injection and tablets: adenoma of the prostate; acute peptic ulcer; pylori duodenal stenosis; glaucoma; pregnancy and lactation; hypersensitivity to the product. Ointment and cream should not be administered to patients with history data of hypersensitivity to the product.

Administration:

Parenteral administration: in severe allergic reactions 1-2 ampoules intramuscularly or intravenously.

Oral administration: adults - 25 mg (1 tablet.) 3-4 times daily (up to 150 mg, if necessary);

children over 5 years: 1 tablet, 2-3 times daily.

External application: affected area should be treated once or several times a day by applying a thin layer of ointment or cream.



Medical action:

Chloropyramine is known as a competitive reversible H1-receptor antagonist (also known as an H1 inverse agonist), meaning that it exerts its pharmacological action by competing with histamine for the H1 subtype histamine receptor. By blocking the effects of histamine, the drug inhibits the vasodilation, increased vascular permeability, and tissue edema associated with histamine release in the tissue. The H1-antagonistic properties of chloropyramine can be used by researchers for the purposes of blocking the effects of histamine on cells and tissues. In addition, chloropyramine has some anticholinergic properties.

Chloropyramine's anticholinergic properties and the fact that it can pass through the blood–brain barrier are linked to its clinical side effects: drowsiness, weakness, vertigo, fatigue, dryness in the mouth, constipation, and rarely - visual disturbances and increase of intraocular pressure.

Precautions:

Chloropyramine should not be used internally with alcohol, sedative drugs and hypnotics because of the potentiation of the effects. It should be used with caution in patients suffering from hyperthyroidism, cardiovascular diseases, and bronchial asthma. In children, it can induce agitation, and in many adult patients, dizziness may be observed. Because of the pronounced sedative effect, the preparation should be prescribed cautiously in drivers and people working with machines.



Side effects:

Upon parenteral or oral administration, Chloropyramine can induce drowsiness, weakness, vertigo, tiredness, dryness of mouth, constipation, and more rarely vision disorders and intraocular pressure elevation. Occasionally, the external application may cause contact allergy and photosensitization.

Overdosage:

If an overdose situation happens seek emergency help.