Each box contains 60 pills.
A pill contains 5 mg of Desloratadine.
Desloratadine is used for treating allergy symptoms and chronic hives. It may also be used for other conditions as determined by your doctor. Desloratadine is an antihistamine. It works by blocking the action of histamine to relieve allergy symptoms, such as sneezing, runny nose, and itchy or watery eyes, and to relieve itching and rash due to chronic hives.
Contra - indications:
Do not use desloratadine if: you are allergic to any ingredient in desloratadine or to loratadine
Contact your doctor or health care provider, right away if any of these apply to you.
According to the package insert. The usual dose for adults and adolescents, 12 years is 5 mg with or without food. The drug may be due to its long half-life of 27 hours may be administered once daily. Children under 12 years are administered in an age-adjusted dosing the solution.
Desloratadine is a non-sedating, long-acting histamine antagonist with selective peripheral H1-receptor antagonist activity. After oral administration, desloratadine selectively blocks peripheral histamine H1-receptors because the substance is excluded from entry to the central nervous system.
Desloratadine has demonstrated anti-allergic properties from in vitro studies. These include inhibiting the release of pro-inflammatory cytokines such as IL-4, IL-6, IL-8, and IL-13 from human mast cells/basophils, as well as inhibition of the expression of the adhesion molecule P-selectin on endothelial cells. The clinical relevance of these observations remains to be confirmed.
In a multiple dose clinical trial, in which up to 20 mg of desloratadine was administered daily for 14 days, no statistically or clinically relevant cardiovascular effect was observed. In a clinical pharmacology trial, in which desloratadine was administered at a dose of 45 mg daily (nine times the clinical dose) for ten days, no prolongation of QTc interval was seen.
No clinically relevant changes in desloratadine plasma concentrations were observed in multiple-dose ketoconazole and erythromycin interaction trials.
Desloratadine does not readily penetrate the central nervous system. In controlled clinical trials, at the recommended dose of 5 mg daily, there was no excess incidence of somnolence as compared to placebo. Desloratadine given at a single daily dose of 7.5 mg did not affect psychomotor performance in clinical trials. In a single dose study performed in adults, desloratadine 5 mg did not affect standard measures of flight performance including exacerbation of subjective sleepiness or tasks related to flying.
Desloratadine may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use desloratadine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Do not change your dose or take desloratadine more often than prescribed without checking with your doctor. Drowsiness may occur if you take more of desloratadine than prescribed.
Desloratadine may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking desloratadine for a few days before the tests.
Desloratadine should be used with extreme caution in children younger than 12 years old; safety and effectiveness in these children have not been confirmed.
Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking desloratadine while you are pregnant. Desloratadine is found in breast milk. Do not breast-feed while taking desloratadine.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome: Dizziness; drowsiness; dry mouth; menstrual pain; muscle pain; nausea; a sore throat; tiredness; upset stomach.
Seek medical attention right away if any of these severe side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); dark urine; fast or irregular heartbeat; pale stools; seizures; yellowing of the skin or eyes.
If an overdose situation happens seek emergency help.