Each box contains 60 pills.
A pill contains 10 mg of Domperidone.
Domperidone 10mg tablets belong to a class of medicines called
Domperidone works by helping to move food faster through your food pipe (oesophagus), stomach and gut. This is so that it does not stay in the same place for too long. It also helps stop food flowing the wrong way back up your food pipe.
Domperidone can be used for the following:
• To stop or prevent you feeling sick (nausea) or being sick (vomiting).
• To stop or prevent indigestion or feeling of fullness during or shortly
after a meal.
• To treat the feeling of stomach discomfort or heartburn caused by the
flow of the stomach contents back into your food pipe.
• To stop or prevent children feeling sick (nausea) or being sick (vomiting
Contra - indications:
Do not take this medicine if you:
• are allergic (hypersensitive) to domperidone or any of the other ingredients of Domperidone 10mg Tablets (listed under section 6,).
Signs of an allergic reaction include a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.
• have a tumour of the pituitary gland (prolactinoma).
• have black, tarry bowel motions (stools) or notice blood in your bowel motions. This could be a sign of bleeding from the stomach or
• have a blockage or tear in your intestines
• have or have had liver problems
Do not take domperidone if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking domperidone.
Always take these tablets exactly as your doctor has told you.
• You should check with your doctor or pharmacist if you are not sure.
Taking this medicine
• Swallow the tablets whole with a drink of water.
• Take the tablets 15 to 30 minutes before a meal and, if needed, before you go to bed.
• Do not crush or chew them.
The usual dose is
Adults and adolescents (over 12 years and who weigh 35kg or more):
Take one or two domperidone tablets (10 or 20mg) 3 to 4 times a day. Do not take more than 8 tablets (80mg) in a day.
Use in children
Do not give Domperidone tablets to children under 12 years of age and weighing less than 35kg.
People with kidney problems:
Your doctor may tell you to take a lower dose or to take the medicine less
Domperidone is a peripheral dopamine (D2) and (D3) receptor antagonist. It provides relief from nausea by blocking receptors at the chemoreceptor trigger zone (a location in the nervous system that registers nausea) at the floor of the fourth ventricle (a location near the brain). It increases motility in the upper gastrointestinal tract to a moderate degree and increases lower esophageal sphincter pressure by blocking dopamine receptors in the gastric antrum and the duodenum. It blocks dopamine receptors in the posterior pituitary gland increasing the release of prolactin which in turn increases lactation. Domperidone may be more useful in some patients and cause harm in others by way of the genetic characteristic of the person, such as polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and α1D--adrenoceptor ADRA1D gene.
Take special care with this medicine
Check with your doctor or pharmacist before taking these tablets if you:
• have any kidney problems. If you take domperidone over a long period, your doctor may want to lower the amount you use. This will depend on how severe your kidney problems are.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking domperidone. Do this even if they have applied in the past.
Other medicines and Domperidone tablets:
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you can buy without a prescription, including herbal medicines. This is because Domperidone can affect the way some other medicines work. Also, some medicines can affect the way Domperidone works. Do not use Domperidone and tell your doctor if you are taking any of the following:
Examples of medicine which can affect Domperidone are:
• Ketoconazole tablets or liquid for fungal infections.
• Antibiotics for infections (such as erythromycin).
Pregnancy, breastfeeding and fertility:
Talk to your doctor or pharmacist before taking domperidone if:
• you are pregnant, might become pregnant or think you may be pregnant.
• You are breastfeeding. It is best not to take domperidone if you are breastfeeding. This is because small amounts of this medicine may pass into the mother’s milk.
Domperidone may be associated with an increased risk of heart rhythm disorder and cardiac arrest. This risk may be more likely in those over 60 years old or taking doses higher than 30mg per day.
Domperidone should be used at the lowest effective dose in adults and children. Like all medicines, these tablets can cause side effects although not everybody gets them. Stop taking domperidone and see your doctor or go to a hospital straight away if:
• You get swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing. You could also notice an itchy, lumpy rash (hives) or nettle rash (urticaria). This may mean you are having an allergic reaction to domperidone.
• You notice any uncontrolled movements. These include irregular eye movements, unusual movements of the tongue, and abnormal posture such as a twisted neck, trembling and muscle stiffness. This is more likely to happen in children. These symptoms should stop once you stop taking domperidone.
• You have a very fast or unusual heartbeat. This could be a sign of a life-threatening heart problem.
• You have a fit (seizure).
The other side effects include:
Common (affects less than 1 in 10 people)
• Dry mouth
Uncommon (affects less than 1 in 100 people)
• Lowering of sexual drive (libido) in men
• Feeling anxious
• Feeling drowsy
• Itchy skin. You may also have a rash
• Unusual production of breast milk in men and women
• Painful or tender breasts
• A general feeling of weakness
Frequency cannot be estimated from the available data
• Feeling agitated or irritable
• Feeling more nervous than usual
• Abnormal eye movements
• Inability to urinate
• Breast enlargement in men
• In women, menstrual periods may be irregular or stop
• A blood test shows changes in the way your liver is working.
Some patients who have used Domperidone for conditions and dosages requiring longer term medical supervision have experienced the following unwanted effects:
Restlessness; swollen or enlarged breasts, unusual discharge from breasts, irregular menstrual periods in women, difficulty breastfeeding, depression, hypersensitivity. Side effects such as feeling drowsy, nervous, agitated or irritable or having a fit are more likely to happen in children.
If an overdose situation happens seek emergency help.