Salbutamol

Salbutamol 60 tabs x 4 mg
Substance

Indications:

Salbutamol is indicated to treat disorders accompanied by bronchospasm: asthma, chronic spastic bronchitis, and emphysema.

Contraindications:

It is not indicated to intake Salbutamol if there exists hypersensitivity to the components of the preparation, I trimester of pregnancy, breastfeeding, under the age of 2 years.

Administration:

Adults and children over 12 years administration:

The common dosage is initiated with 2-4 mg, to a maximum of four times per day. The required dose can be repeated, even though the next dose can be administered no sooner than above 6 hours. If the action is insufficient, after consultation with the doctor the dose may be gradually increased, but not to exceed a maximum nictemeral dose of 8 mg 4 times a day. A single dose administration that exceeds 4 mg should be administered only in case if it lacks the therapeutic effect at lower doses.

In the elderly  and individuals with hypersensitivity to sympathomimetic amines, it is necessary to administer an initial dose of 2 mg 4 times per day. The maximum nictemeral dose is 32 mg salbutamol.

Children aged 6-12 years:

The initial dose is 2 mg 3-4 times a day. The required dose can be repeated, even though the next dose can be administered no sooner than above 6 hours. If the action is not sufficient, after consultation with the doctor the dose may be increased gradually, but not to exceed a maximum nictemeral dose of 6 mg 4 times a day (24 mg).

Children aged 2 to 6 years: 1-2 mg (0.1 mg / kg), 3-4 times a day.

Medical action:

Salbutamol is a selective agonist of the beta2-adrenergic receptor, with relaxing action on the bronchial muscles. Prevents the release of histamine, the slow-release substance from mast cells and chemotaxis factor for neutrophils. Induces an insignificant positive inotropic and chronological effect, coronary dilatation practically does not reduce blood pressure. Manifests tocolytic action: decreases the  tone and contractile activity of the myometrium.

Salbutamol is rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved in approximately 2 hours.

The drug is metabolized in the liver and is excreted as metabolites.

Precautions:

The drug should be administered with caution in patients with coronary heart disease, heart failure, arrhythmia, hypertension, epilepsy, glaucoma, and diabetes.

This medicinal product contains lactose, so it can not be taken by patients with rare hereditary problems of galactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Administration of salbutamol is contraindicated in I trimester of pregnancy, the second and third trimesters of pregnancy is only possible if the intended benefits to the mother justify the potential risk to the fetus.

During treatment with salbutamol, breastfeeding will be stopped.

Side effects:

Are possible: restlessness, tremor, palpitations, headache, tachycardia, palpitations powerful muscle twitching, insomnia, rarely - drowsiness, skin redness, irritability. In children, 2-6 years the most common side effects are irritability and nervousness.

Allergic reactions: anaphylaxis, angioedema, bronchospasm, urticaria, and rash.

Overdosage:

Symptoms: nausea, vomiting, hyperexcitability, hallucinations, tachycardia, ventricular flutter, dilated peripheral vessels, lowering blood pressure, hypoxemia, acidosis, hypokalemia, hyperglycemia, muscle tremors, headache.